Out-of-hospital cardiac arrest (OHCA) is a worldwide leading cause of death and a major health issue. Despite improvements in management, the prognosis of patients resuscitated after OHCA remains poor.

The high mortality after OHCA is considered to be a consequence of post-cardiac arrest syndrome (PCAS).

Main components of PCAS are ischemic tissue injury, systemic inflammatory response, combining clinical features of cardiogenic with sepsis-like shock and acute respiratory distress syndrome (ARDS), ultimately leading to multiorgan failure and death.

Early goal directed therapy (EGDT) is a therapy with a specific protocol in place that is followed by physicians in the management of severe sepsis and septic shock cases.

Despite the fact that EGDT implemented as soon as possible after diagnosis in septic shock patients was proven to reduce mortality in patients, data for EGDT as a strategy are scarce.

Furthermore, no previous studies evaluated the efficacy of EGDT with hemodynamic and ventilatory optimization after OHCA.

Due to the lack of profound knowledge, most of the current treatment strategies for PCAS are focused on direct cause of OHCA treatment and are ineffective in survival improvement.

The main aim of the project is to develop a decision support mobile application for the clinicians to be used when deciding on the EGDT strategy for their patients, resulting in the reduction of early mortality after OHCA.

The benefit of invasive monitoring in critically ill is still questionable. To implement an easy to use digital tool - mobile application, enabling noninvasive, point-of-care assessment of patient’s health and providing clinical decision support based on EGDT is thus of paramount importance. Implementation of the tool will directly translate into possibility for advanced assessment of OHCA patients, irrespectively of financial status or access to invasive monitoring methods.

Development of our innovative mobile application is based on novel calculator designed by the project team. Operating through simple non-invasive input data based on reliable mathematical calculations and providing advanced parameters as an output, could bring an effective tool for data collecting, processing and monitoring.

Output data will guide physicians and advise them on further therapeutic management plan to achieve the hemodynamic, metabolic and respiratory goals which are based on current recommendations for critically ill and on international recommendations for management of OHCA patients and patients with acute heart failure.

Mobile application brings a possibility for the detailed and advanced assessment of OHCA patients in hospitals and treating centers right in the critical early stage of PCAS.

Importantly, basic data requirements for the calculator, will enable worldwide use of the application, irrespectively of access to invasive monitoring methods at the treating centers and hospitals. The expected final goal of the project is to improve the quality of care and outcomes of OHCA patients.